Senior Scientist

Senior Scientist

Introduction to role

Are you ready to make a significant impact in the field of Cell Therapy Discovery? We are on the lookout for a dynamic Senior Scientist with expertise in molecular biology, immunology, and gene editing. This hands-on role involves leading lab-based research, developing cutting-edge assays, and interpreting scientific data within a collaborative environment. If you have a creative mindset and thrive on exploratory discovery projects, this is your chance to contribute to the advancement of innovative Cell Therapy products. Join us and be part of a team that values strong communication skills and cross-functional collaboration!

Accountabilities

• Independently conceive and execute in vitro immunologic cell therapy experiments requiring extensive knowledge in molecular and cellular biology, flow cytometry, and gene editing.

• Assess and interpret data with high integrity, presenting findings to leadership in a clear and concise manner.

• Collaborate effectively in a fast-paced environment to drive project advancement decisions.

• Maintain a well-developed understanding of drug discovery approaches and apply broader functional knowledge to support diverse project groups.

• Stay informed about the latest scientific advancements in the field, sharing and discussing relevant external literature with peers.

• Work creatively to support the development of assays for validating novel cell-based therapies.

• Ensure compliance with Good Laboratory Practice, Safety, Health, and Environment standards, as well as AstraZeneca's internal standards and external regulations.

Essential Skills/Experience

• PhD in Immunology, Bioengineering, Molecular or Cell Biology, or related fields with 0-2 years of experience post-PhD.

• Extensive experience in cell culture of primary human immune cells and Immunology functional assays, preferably involving T lymphocytes.

• Proficiency with multi-color flow cytometry experiment design, acquisition, and analysis.

• Experience with conventional molecular and cell biology techniques.

• Familiarity with Regulatory T cells (Tregs) and/or effector T cells-based signaling pathways and cytokines circuits preferred.

Desirable Skills/Experience

• Previous experience in the development and characterization of CAR-T cells, TCR-T cells strongly desirable.

• Previous experience in T cell-based immunotherapy of autoimmune diseases and/or cancers.

• Familiarity with gene editing techniques (e.g., CRISPR/Cas, mRNA, viral engineering, etc.).

• Previous experience supporting in vivo studies (MoA, tolerability, efficacy, etc.).

• Biotechnology or pharmaceutical industry experience preferred.

At AstraZeneca, you'll find yourself among a community of highly qualified scientists who are both supportive and challenging. We foster an environment of continuous learning and information sharing, where constructive critique drives us toward groundbreaking solutions. Here, dedication is key as we courageously tackle unknowns and make bold decisions that can change patients' lives. With countless opportunities for growth across our global Therapy Areas, you'll be empowered to make a profound impact through research that truly matters.

Ready to take the next step in your career? Apply now and join us in making a difference!

Date Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.